Peridone

Products - Gastro Prokinetic

Composition:

Peridone Tablet: Each tablet contains Domperidone BP10 mg (as Domperidone Maleate BP).
Peridone Suspension: Each 5 ml suspension contains Domperidone BP 5 mg.

Pharmacology:

Peridone is a dopamine antagonist that principally blocks the dopamine receptors located in the chemoreceptor trigger zone (CTZ) and stomach. Its gastroprokinetic action is based on its blocking effect of dopamine receptors that have an influence on the motility of gastro-intestinal tract. Due to its weak penetration across the blood-brain barrier, Peridone has almost no effect on the dopaminergic receptors in the brain therefore excluding psychotropic and neurologic side effects. Peridone restores normal motility and tone of the upper gastro-intestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis and regulates contraction of the pylorus. Peridone also increases esophageal peristalsis and lower esophageal sphincter pressure, and thus prevents regurgitation of gastric content.

Indications:

1. Dyspeptic symptom complex, often associated with delayed gastric emptying, Gastroesophageal reflux and esophagitis:
   Epigastric sense of fullness, feeling of abdominal distension, upper abdominal pain Eructation, flatulence, early satiety, Nausea and vomiting, Heartburn with or without regurgitations of gastric contents in the mouth, Diabetic gastro paresis, Non-ulcer dyspepsia
2. Acute nausea and vomiting of functional, organic, infectious, dietetic origin or induced by radiotherapy or drug therapy or induced in migraine.
3. Parkinson’s disease: In dopamine-agonist induced nausea and vomiting.
4. Radiological studies: speeding barium transit in follow-through radiological studies.

Dosage and Administration:

Peridone should be taken 15-30 minutes before meals and, if necessary, before retiring. The usual recommended oral dose of Domperidone is as follow:
Adults: 10-20 mg (1-2 Peridone tablet or 10-20 ml Peridone suspension), every 4-8 hours daily.
Children: 2-4 ml Peridone suspension/10 kg or 0.4-0.8 ml Peridone Drops/10 kg body weight, every 4-8 hours daily. In dyspeptic symptom: The recommended oral dose for Adults: 10-20 mg (1-2 Peridone tablet or 10-20 ml Peridone suspension), every 4-8 hours daily. Children: 0.2-0.4 mg/Kg (2-4 ml Peridone suspension/10 Kg or 0.4-0.8 ml Peridone Drops/10 kg) body weight, every 4-8 hours daily. In acute and sub-acute conditions (mainly in acute nausea and vomiting): The recommended oral dose for Adults: 20 mg (2 Peridone tablet or 20 ml Peridone suspension), every 4-8 hours daily Children: 0.2-0.4 mg/Kg (2-4 ml Peridone suspension/10 Kg or 0.4-0.8 ml Peridone Drops/10 kg) body weight, every 4-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

Side Effects:

Domperidone may produce hyperprolactinemia (1.3%). This may result in galactorrhea, breast enlargement, soreness and reduced libido. Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash and itching (0.1%) may occur during treatment with domperidone. Extrapyramidal reactions are seen in 0.05% of patients in clinical studies.

Precautions:

Domperidone should be used with absolute caution in case of children because there may be increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood-brain barrier. Since domperidone is highly metabolized in liver, it should be used with caution in patient with hepatic impairment.

Contraindication:

Peridone is contraindicated to patients having known hypersensitivity to this drug and in case of neonates. Domperidone should not be used whenever gastro-intestinal stimulation might be dangerous i.e., gastro-intestinal hemorrhage, mechanical obstruction or perforation. Also contraindicated in patients with prolactin releasing pituitary tumor (prolactinoma).

Use in Pregnancy and Lactation:

Pregnant woman: The safety of domperidone has not been proven and it is therefore not recommended during pregnancy. Animal studies have not demonstrated teratogenic effect in the fetus. Lactating mother: Peridone may precipitate galactorrhea and improve postnatal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.